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Update: The Bills and 49ers have confimed their inactive players for Sunday Night Football, with Nick Bosa, Trent Williams, and Dalton Kincaid all scratched for tonight’s matchup. Learn how this impacts stat projections and Bills-49ers odds.
The Buffalo Bills will face off against the San Francisco 49ers in Week 13 of the NFL season at Highmark Stadium on Sunday, scheduled to start at 8:20 p.m. EST, with all eyes on this vital clash in the primetime slot at the end of Thanksgiving weekend.
After the team at Dimers simulated the game 10,000 times, the best bet has been determined to be Bills -6.5 (-120 odds), with the home team looking to keep their winning ways going after defeating the Chiefs before the bye last week.
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Now, into the rest of our Sunday Night Football predictions!
Explore the interactive widget below to discover the latest spread, over/under, and moneyline odds and probabilities for the 49ers-Bills game at Highmark Stadium.
This prediction and best bet for Sunday’s NFL matchup between the 49ers and Bills is from Dimers.com, a leader in sports betting predictions.
Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.
The key information you need before the 49ers vs. Bills Sunday Night Football game.
The latest and best odds for the NFL primetime showdown between the 49ers and Bills.
The odds and lines presented in this article are the best available from selected sports betting site at the time of publication and are subject to change.
Using cutting-edge data analysis and advanced algorithms, the experts at Dimers have executed 10,000 simulations of Sunday’s 49ers vs. Bills matchup.
According to Dimers’ renowned predictive analytics model, the Bills are more likely to defeat the 49ers at Highmark Stadium. This prediction is based on the model giving the Bills a 75% chance of winning the game.
Elsewhere on the betting board, Dimers predicts that the Bills (-6.5) have a 54% chance of covering the spread, while the 44.5-point over/under has a 52% chance of staying under.
As always, these predictions and probabilities are accurate at the time of publication but are subject to change.
Our top pick for the 49ers vs. Bills Week 13 NFL matchup is to bet on the Bills -6.5 (-120).
This betting advice is based on cutting-edge modeling and valuable betting intelligence, designed to deliver you the best possible plays.
Dimers’ projected final score for the San Francisco vs. Buffalo game on Sunday has the Bills winning 25-18.
This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.
NFL player prop bets are an enjoyable way to wager on Sunday’s game without necessarily betting on its outcome.
This article features the most likely first and anytime touchdown scorers for the 49ers and Bills, along with projected player stats.
Get ready for Sunday’s matchup between the 49ers and Bills in Week 13 of the National Football League season at Highmark Stadium, which is scheduled to start at 8:20 p.m. EST. We emphasize that all of the NFL best bets and NFL predictions on this page are based on 10,000 data-driven simulations of the 49ers vs. Bills game, and they are accurate at the time of publishing. They aim to help you make better decisions when placing bets at online sportsbooks.
It is important to gamble responsibly and consult reliable sources for the latest and most accurate information when making online betting decisions.
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